On August 25, 2011, Brain, Christopher Thomas; Cho, Young Shin; Giraldes, John William; Lagu, Bharat; Levell, Julian; Luzzio, Michael; Perez, Lawrence Blas; Wang, Yaping; Yang, Fan published a patent.Recommanded Product: 1198284-94-4 The title of the patent was Preparation of pyrrolopyrimidine derivatives for use as CDK4/6 inhibitors. And the patent contained the following:
Title compounds I [A = CH or N; L = bond, C(O), or S(O)2; R1 = alkyl, (un)substituted cycloalkyl, PH, piperidinyl, or tetrahydropyranyl; R2 = (un)substituted diazabycycloheptanyl, diazaspirononanyl, diazabicyclooctanyl, etc.; R4 = H, D, CH3, etc.; R8, R9, R10, and R11 independently = H or D], and their pharmaceutically acceptable salts, are prepared and disclosed as cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in CDK4/cyclin D1 enzymic activity assays, e.g., II demonstrated an IC50 value of 0.008 to 0.016 μM. The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).Recommanded Product: 1198284-94-4
The Article related to pyrimidine pyrrolo derivative preparation cdk4 cdk6 inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 1198284-94-4
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