On April 30, 2021, Zhou, Shiyang; Zou, Huiying; Huang, Gangliang; Chen, Guangying; Zhou, Xueming; Huang, Shuheng published an article.Recommanded Product: Methyl 2-cyclopentanonecarboxylate The title of the article was Design, synthesis and anti-rheumatoid arthritis evaluation of double-ring conjugated enones. And the article contained the following:
Four series of double-ring conjugated enones were designed, synthesized and studied for the inhibition of synovial cell activity through the modification of Dysodensiol K core structure, double-ring, double-bond and double-carbonyl groups. For the in vitro synovial cell assay of rats, compound I and II exhibited good inhibitory activities, with IC50 values of 2.71 ± 0.18 and 2.68 ± 0.16μM, resp. At the same time, the LDH release and LD50 test results revealed that the target compounds had low cytotoxicity and acute toxicity. For the in vivo CIA model test through oral administration, compounds I and II exhibited a similar effect to pos. control group methotrexate. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Recommanded Product: Methyl 2-cyclopentanonecarboxylate
The Article related to dysodensiol k analog preparation antirheumatoid arthritis, synovial cell activity inhibitor dysodensiol k analog, conjugated enones, design, modification, synovial cell, synthesis and other aspects.Recommanded Product: Methyl 2-cyclopentanonecarboxylate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics