On August 6, 2021, Zhao, Yingsheng; Jiangya, Qiqi; Shi, Daqing published a patent.Application of 141940-37-6 The title of the patent was Preparation of aniline para-trifluoromethyl derivative. And the patent contained the following:
The present invention relates to the preparation of aniline para-trifluoromethyl derivative In particular, the preparation method comprises the following steps: (1) adding aniline derivative, 4,5-dichlorofluorescein, potassium persulfate and sodium trifluoromethyl sulfinate in a glass reaction tube, and using DMSO as a solvent to react at room temperature (23-25°) under a 40W blue LED to obtain aniline para-trifluoromethyl derivative, and (2) after the reaction is completed, the product is separated and purified by column chromatog. to obtain the para-trifluoromethylated aniline derivative The present invention has following advantages: (1) the raw material is readily available in many kinds; (2) the products obtained by the method of the present invention are of various types and can be directly applied to the modification of drug mols.; (3) at the same time, the synthetic route is safe and easy, the cost is low, the reaction operation and post-treatment process is simple, the selectivity is good, the side reactions are few, and the reaction can be scaled up. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Application of 141940-37-6
The Article related to trifluoromethyl sulfinate aniline photochem trifluoromethylation, aniline trifluoromethyl derivative preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.Application of 141940-37-6
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