On May 10, 2018, Yu, Wensheng; Tong, Ling; Selyutin, Oleg; Chen, Lei; Hu, Bin; Zhong, Bin; Hao, Jinglai; Ji, Tao; Zan, Shuai; Yin, Jingjun; Ruck, Rebecca T.; Curry, Stephanie; McMonagle, Patricia; Agrawal, Sony; Rokosz, Laura; Carr, Donna; Ingravallo, Paul; Bystol, Karin; Lahser, Frederick; Liu, Rong; Chen, Shiying; Feng, Kung-I.; Cartwright, Mark; Asante-Appiah, Ernest; Kozlowski, Joseph A. published an article.Computed Properties of 3976-69-0 The title of the article was Discovery of MK-6169, a Potent Pan-Genotype Hepatitis C Virus NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Substitutions. And the article contained the following:
We describe the discovery of MK-6169 (I), a potent and pan-genotype hepatitis C virus NS5A inhibitor with optimized activity against common resistance-associated substitutions. SAR studies around the combination of changes to both the valine and aminal carbon region of elbasvir led to the discovery of a series of compounds with substantially improved potency against common resistance-associated substitutions in the major genotypes, as well as good pharmacokinetics in both rat and dog. Through further optimization of key leads from this effort, MK-6169 (I) was discovered as a preclin. candidate for further development. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Computed Properties of 3976-69-0
The Article related to imidazolylbenzooxazinoindole preparation mk6169 antiviral hepatitis c virus ns5a inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Computed Properties of 3976-69-0
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