On September 7, 2001, Yamabe, Haruko; Okuyama, Masahiro; Nakao, Akira; Ooizumi, Mitsuru; Saito, Ken-ichi published a patent.Computed Properties of 114312-57-1 The title of the patent was Preparation of cyclic amide derivatives as sigma receptor ligands. And the patent contained the following:
The title compounds I [X is alkyl, aryl, a heterocyclic group, etc.; Q is CH2, CO, O, etc.; n is an integer of 0 to 5; R1 and R2 are each hydrogen, alkyl, etc.; and B is Q1, etc.; A = (CH2)m; R3, R4, R5 and R6 are each hydrogen, halogeno, alkoxy, etc.; m is 1 or 2] are prepared In an in vitro test for inhibition of sigma-2 receptor binding, 4-bromo-2-[[1-[2-(4-fluorophenyl)-2-oxoethyl]piperidin-4-yl]methyl]isoindolin-1-one hydrochloride showed the Ki value of 2.8 nM. Formulations are given. The experimental process involved the reaction of Ethyl 3-fluoro-2-methylbenzoate(cas: 114312-57-1).Computed Properties of 114312-57-1
The Article related to cyclic amide preparation sigma receptor ligand, isoindolinone preparation sigma receptor ligand, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Computed Properties of 114312-57-1
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