On April 8, 2021, Wu, Lingyun; Wang, Cailin; Xu, Xiongbin; Tong, Haijun; Chen, Shuhui published a patent.HPLC of Formula: 37480-41-4 The title of the patent was Preparation of heteroaryl compounds as PD-1/PD-L1 inhibitors for treatment of cancer. And the patent contained the following:
The title compounds represented by general formula I [wherein ring A is selected from Ph, 5-10 membered heteroaryl or 5-10 membered heterocycloalkenyl; L is selected from a single bond, -C(=O)NH-, -CH=CH-, -O-CH2- or -NH-; X is selected from -CH- or N; when Y is selected from a single bond, -CH2- or -CH(CH3)-, Z is selected from NR4, or when Y is selected from NR5, Z is selected from -CH2-, where R4 and R5 are each independently selected from H, C1-6 alkyl, C1-6 alkyl-NH-, C3-8 cycloalkyl, etc.; R1 is selected from H, C1-3 alkyl, C1-3 alkoxy, pyridyl-C1-3 alkane-O- or C1-3 alkyl-NH-; R2 and R3 are each independently selected from H, F, Cl, Br, I, CN, etc.; R6 is selected from H, C1-6 alkyl, C0-6 alkyl-C3-6 cycloalkyl, C0-6 alkyl-3-10 membered heterocycloalkyl, C0-6 alkyl-NH-C1-6 alkyl, etc.] or pharmaceutically acceptable salts or isomers thereof were prepared as PD-1/PD-L1 inhibitors. For example, compound II was prepared in a multi-step synthesis. The title compounds can be used for the treatment of cancers. The experimental process involved the reaction of Methyl 1-methyl-4-oxocyclohexanecarboxylate(cas: 37480-41-4).HPLC of Formula: 37480-41-4
The Article related to preparation heteroaryl compound pd1 pdl1 inhibitor treatment human cancer, benzoxazole pyridine naphthalene thiazole pyrazine pyrazole pyrimidine, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.HPLC of Formula: 37480-41-4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics