On April 25, 2018, Wang, Mingliang; Han, Jilai; Si, Xiaojia; Hu, Yimin; Zhu, Jidong; Sun, Xun published an article.Application In Synthesis of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the article was Effective approach to ureas through organocatalyzed one-pot process. And the article contained the following:
An efficient approach to N,N’-unsym. substituted ureas ArN(R1)C(O)NH(R2) (R1 = H; R2 = n-Bu, c-hexyl, Bn, etc.; Ar = 4-MeC6H4, 4-MeOC6H4, 4-F3CC6H4, 3-BrC6H4) has been developed through the ammonolysis of N-Boc protected anilines with amines prompted by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD). Moreover, a convenient protocol for the synthesis of the sym. N,N’-substituted ureas RNHC(O)NHR (R = Ph, 2-ClC6H4, 4-IC6H4, etc.) by one-pot diammonolysis of Boc2O with amines catalyzed by DABCO has also been achieved. With broad substrate scope and mild conditions, these two methods demonstrate practical preparation of both unsym. and sym. ureas. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Application In Synthesis of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate
The Article related to unsym sym urea preparation, amine tert butyl dicarbonate ammonolysis diammonolysis triazabicyclodecene dabco catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Application In Synthesis of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate
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