On May 6, 2022, Tang, Ling; Jiang, Shuangshuang; Huang, Xinmiao; Song, Zhiyong; Wang, Jian-bo; Ma, Ming; Chen, Bo; Ma, Yuanhong published an article.Safety of Ethyl indolizine-1-carboxylate The title of the article was Cascade of C(sp2)-H Addition to Carbonyl and C(sp2)-CN/C(sp2)-H Coupling Enabled by Bronsted Acid: Construction of Benzo[a]carbazole Frameworks. And the article contained the following:
Herein, an unprecedented cascade reaction of C(sp2)-H addition to carbonyl and the C(sp2)-CN/C(sp2)-H coupling of 2-(2-oxo-2-arylethyl)benzonitriles with indoles enabled by com. available TsOH·H2O was reported. The protocol represented the first metal-free C(sp2)-CN/C(sp2)-H coupling, affording a new route for the synthesis of various benzo[a]carbazole derivatives I [R1 = H, 3-OMe, 3-F, etc.; R2 = Ph, 2-MeC6H4, 4-ClC6H4, etc.; R3 = H, Me, Ph; R4 = H, Me, Et; R5 = H, 9-F, 8-Br, etc.] with a broad substrate scope, high yields, and simple conditions. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Safety of Ethyl indolizine-1-carboxylate
The Article related to benzocarbazole preparation, indole benzonitrile cascade addition coupling, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Safety of Ethyl indolizine-1-carboxylate
Referemce:
Ester – Wikipedia,
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