Sarnowski, Matthew P.; Kang, Chang Won; Elbatrawi, Yassin M.; Wojtas, Lukasz; Del Valle, Juan R. published an article in 2017, the title of the article was Peptide N-Amination Supports β-Sheet Conformations.Synthetic Route of 53838-27-0 And the article contains the following content:
The conformational heterogeneity of backbone N-substituted peptides limits their ability to adopt stable secondary structures. Herein, we describe a practical synthesis of backbone aminated peptides that readily adopt β-sheet folds. Data derived from model N-amino peptides suggest that extended conformations are stabilized through cooperative steric, electrostatic, and hydrogen-bonding interactions. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Synthetic Route of 53838-27-0
The Article related to backbone aminated peptide beta sheet conformation, foldamers, peptidomimetics, secondary structures, β-hairpins, β-strands, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Synthetic Route of 53838-27-0
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