On November 15, 2021, Said, Mona F.; Georgey, Hanan H.; Mohammed, Eman R. published an article.Synthetic Route of 517-23-7 The title of the article was Synthesis and computational studies of novel fused pyrimidinones as a promising scaffold with analgesic, anti-inflammatory and COX inhibitory potential. And the article contained the following:
Addressing the global need for the development of safe and potent NSAIDs, new series of oxadiazolo and thiadiazolo fused pyrmidinones were synthesized and initially tested for their analgesic activity. All tested compounds showed promising analgesic activity compared with the reference standard indomethacin. Moreover, anti-inflammatory activity evaluation, ulcerogenic liability, and in vitro COX-1, COX-2 enzyme inhibition assays were also performed for the most active derivatives The methoxyphenyl piperazinyl derivative I showed analgesic activity surpassing indomethacin with protection of 100%, and 83%; resp. Also I showed good anti-inflammatory activity with relatively lower ulcer index compared with other tested compounds, and potent COX-1 and COX-2 inhibitory activity with IC50 = 0.140, 0.007μm, resp., and with a selectivity index of 20.00 which was better than the reference standards and the other tested congeners. Addnl., three compounds revealed moderate selectivity (SI = 3.53, 3.70 and 5.87, resp.). Moreover, in silico physicochem. parameters revealed that the new fused pyrimidinones demonstrated promising pharmacokinetic properties. Furthermore, computational studies in form of 2D-quant. structure-activity relationship (2D-QSAR) and 3D-pharmacophore confirmed the potential analgesic properties of the new target compounds The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Synthetic Route of 517-23-7
The Article related to fused pyrimidinone preparation antiinflammatory physicochem analgesic pharmacophore pharmacokinetic, analgesic, anti-inflammatory, fused pyrimidinones, pharmacophore, qsar study and other aspects.Synthetic Route of 517-23-7
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