On June 17, 2022, Romiti, Filippo; Decultot, Ludovic; Clark, J. Stephen published an article.Electric Literature of 2873-29-2 The title of the article was Convergent Synthesis of the C1-C29 Framework of Amphidinolide F. And the article contained the following:
The complete carbon framework of the macrocyclic marine natural product amphidinolide F has been prepared by a convergent synthetic route in which three fragments of similar size and complexity have been coupled. Key features of the syntheses of the fragments include the stereoselective construction of the THF in the C1-C9 fragment by oxonium ylide (free or metal-bound) formation and rearrangement triggered by the direct generation of a rhodium carbenoid from 1-sulfonyl-1,2,3-triazole, the highly diastereoselective aldol reaction between a boron enolate and an aldehyde with 1,4-control to prepare the C10-C17 fragment, and the formation of the THF in the C18-C29 fragment by intramol. nucleophilic ring opening of an epoxide with a hydroxyl group under acidic conditions. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Electric Literature of 2873-29-2
The Article related to diastereoselective aldol rearrangement nucleophilic ring opening evans tishchenko, amphidinolide f framework synthesis, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Electric Literature of 2873-29-2
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