On May 17, 2019, Qiu, Xing; Sun, Ning; Kong, Ying; Li, Yan; Yang, Xiaobao; Jiang, Biao published an article.Recommanded Product: 882518-89-0 The title of the article was Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction. And the article contained the following:
Using DIPEA as base in N-methyl-2-pyrrolidinone (NMP), lenalidomide underwent regioselective alkylation with bromoesters and Boc-protected bromoamines followed by deprotection to yield lenalidomide derivatives as a library of potential PROTAC reagents. One of the products was coupled to the known BET binding agent JQ1 to yield I; I degraded BET protein in cells and effectively inhibited cancer cell proliferation. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Recommanded Product: 882518-89-0
The Article related to protac library lenalidomide regioselective preparation, regioselective alkylation lenalidomide bromoamine bromoester, bet degradation antitumor activity jq1 lenalidomide conjugate and other aspects.Recommanded Product: 882518-89-0
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