On December 1, 2011, Noguchi, Toshiya; Ushiyama, Fumihito; Horikiri, Hiromasa; Yamamoto, Keiko; Ono, Naoya; Takayama, Tetsuo; Kamiyama, Tomoko published a patent.Product Details of 1198284-94-4 The title of the patent was Preparation of heterocyclic compounds or salts thereof for use as antibacterial agents. And the patent contained the following:
Disclosed is a medicament having a strong antibacterial activity against Gram-pos. bacteria, Gram-neg. bacteria, and resistant bacteria. A compound represented by formula I [a bond containing dotted line and connecting X2 to Y1 represents single bond or double bond; Z1-6 = N, CR; R = H, (halo)alkoxy, OH, halogen, (halo)alkyl, cycloalkyl, CN, NO2, etc.; X1 = (oxo-containing) C1-4 alkylene; X2 = bonding hand, CH; Y1 = spirocyclic group; X3 = C1-4 alkylene, NR'(CH2)m, SOn, bonding hand; R’ = H, C1-6 alkyl; m, n = 0, 1, 2; R1 = C3-6 cycloalkyl, C3-6 cycloalkenyl, aryl, heterocyclic group] or a salt thereof is useful as an antibacterial agent. Thus, compound II was synthesized through a multistep process and showed antibacterial activity against Staphylococcus aureus (MIC 0.03). The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).Product Details of 1198284-94-4
The Article related to heterocyclic antibacterial agent preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Product Details of 1198284-94-4
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