On June 23, 2021, Nicolaou, K. C.; Pan, Saiyong; Shelke, Yogesh; Das, Dipendu; Ye, Qiuji; Lu, Yong; Sau, Susanta; Bao, Ruiyang; Rigol, Stephan published an article.Formula: C12H16O7 The title of the article was A Reverse Approach to the Total Synthesis of Halichondrin B. And the article contained the following:
A new strategy is described for the total synthesis of halichondrin B featuring reversal of the sequential construction of a number of its cyclic ethers from the classical approach by instead forming C-O bonds first followed by C-C bond formation. Employing the Nicholas reaction to generate linear ethers as precursors for the total synthesis of halichondrin B and other members of the halichondrin and eribulin families of compounds, this novel approach provides new opportunities for the development of improved syntheses of these complex and valuable compounds In this Article, we report the syntheses of defined fragments I (I), MN (II), EFG (III), and A (IV). Fragments I and MN were then coupled and elaborated to advanced intermediate IJKLMN, which was joined with fragment EFG to afford, after appropriate elaboration and macrolactonization, the more advanced polycyclic intermediate EFGHIJKLMN. Elaboration of the latter and coupling with fragment A followed by further functionalization completed the total synthesis of halichondrin B through a short and convergent pathway. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Formula: C12H16O7
The Article related to diastereoselective horner wadsworth emmons nozaki hiyama kishi nicholas etherification, halichondrin b total synthesis, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Formula: C12H16O7
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