On December 16, 2009, Metzger, Axel; Qin, Lan-Ying; Cole, Andrew G.; Saionz, Kurt W.; Brescia, Marc-Raleigh; Gstach, Hubert; Wareing, James R.; Zimmermann, Juerg; Brill, Wolfgang K.-D.; Baldwin, John J.; Dolle, Roland E.; Henderson, Ian published an article.Product Details of 53838-27-0 The title of the article was Combined solution-phase and solid-phase synthesis of 2-amino-7,8-dihydropteridin-6(5H)-ones. And the article contained the following:
An efficient and general synthesis of substituted 2-amino-7,8-dihydropteridin-6(5H)-ones I [R1 = i-Bu, MeOCH2CH2, Ph, 3,4-Cl2C6H3, PhCH2CH2; R2 = Me, HOCH2, HO2CCH2CH2, H2N(CH2)4, 4-HOC6H4CH2; R3 = Ph, 4-ClC6H4, 3-pyridyl, etc.] using a combination of solution-phase and solid-phase chem. is described. Solution-phase chem. was used to produce two pyrimidine regioisomers that were separated by flash column chromatog. Utilizing the desired regioisomer II, solid-phase chem. was used to effect the rapid construction of the substituted 2-amino-7,8-dihydropteridin-6(5H)-one system in high overall yield and purity. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Product Details of 53838-27-0
The Article related to pteridinone amino dihydro solution solid phase synthesis, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Product Details of 53838-27-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics