On December 24, 2014, Madanahalli Ranganath Rao, Jagannath; Gurram Ranga, Madhavan; Pachiyappan, Shanmugam published a patent.Category: esters-buliding-blocks The title of the patent was Preparation of spirooxindole derivatives for use as AMPK activators. And the patent contained the following:
Title compounds I [A = bond, (un)substituted aryl, or heteroaryl; B = (un)substituted cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; C = (un)substituted aryl or heteroaryl; X = N or CR3; Y = H, OH, (un)substituted heteroaryl, etc.; Z = bond or a linking moiety; R1 and R2 independently = H or (un)substituted alkyl; R3 and R5 independently = H, halo, CN, NO2, etc.; R4 = H, F, Cl, Br, or I; R6 and R7 independently = H or (un)substituted alkyl; n = 0 to 2], and their pharmaceutically acceptable salts, are prepared and disclosed as AMPK activators. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in AMPK biol. activity assays, e.g., II demonstrated 166% activation of beta 1 at 10 μM. The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Category: esters-buliding-blocks
The Article related to spirooxindole preparation ampk activator, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
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