Kotani, Shunsuke; Sakamoto, Midori; Osakama, Kazuki; Nakajima, Makoto published an article in 2015, the title of the article was A Sterically Congested α-Cyanoamine as a Cyanating Reagent: Cyanation of Acetals and Orthoesters.Product Details of 707-07-3 And the article contains the following content:
The cyanation of acetals and ortho-esters by using a sterically congested α-cyanoamine as a cyanation reagent was investigated. The α-cyanoamine effectively facilitated cyanation in the presence of trichlorosilyl triflate to produce a variety of cyanated adducts in excellent yields. Anal. of the reaction mixture by 1H NMR spectroscopy revealed that trichlorosilyl triflate produced an oxocarbenium cation species as an intermediate. Under optimized conditions the synthesis of the target compounds was achieved using 1,1,1-trifluoromethanesulfonic acid trichlorosilyl ester as a reagent and 2-(dicyclohexylamino)acetonitrile (cyanation agent amine-cyanide) and (dimethoxymethyl)benzene (benzaldehyde acetal), (3,3-dimethoxy-1-propen-1-yl)benzene, (dimethoxymethyl)cyclohexane, 1,1′-[(phenylmethylene)bis(oxymethylene)]bis[benzene], 2-phenyl-1,3-dioxolane (cyclic acetal) as starting materials. The title compounds thus formed included α-(methoxy)benzeneacetonitrile derivatives, α-(methoxy)-1-naphthaleneacetonitrile, 2-methoxy-4-phenyl-2-butenenitrile, α-(2-hydroxyethoxy)benzeneacetonitrile. Ortho-ester reactants included (trimethoxymethyl)benzene, 1,1′,1”-[methylidynetris(oxy)]tris[ethane] and 1,1,1-triethoxypentane. Products therefrom included α,α-dimethoxybenzeneacetonitrile. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Product Details of 707-07-3
The Article related to alkoxy alkanenitrile nitrile cyanation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Product Details of 707-07-3
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