On October 29, 1992, Koda, Akihide; Waragai, Koji; Ono, Yutaka; Ozawa, Hideyuki; Kawamura, Hideki; Maruno, Masao published a patent.Safety of Methyl 1-methyl-4-oxocyclohexanecarboxylate The title of the patent was Preparation of cinnamic acid derivatives as allergy type IV reaction inhibitors. And the patent contained the following:
The title compounds, e.g., cinnamamide derivatives [I; L = (CH:CH)k, (CH2)k; j = 1-6; k = 0-5; R1-R4 = H, NH2, acylamino, di(C1-5 alkyl)amino, halo, HO, AcO, C1-3 alkoxy, CF3, NO2, tetrahydropyranyloxy, PhCH2O; R1R2 = OCH2O) and cinnamic acid esters [II; X3 = CH, COH; R18 = H, C1-6 alkyl; R19 = H, C1-6 alkyl, aryl; R20, R21 = H, C1-6 alkyl, CO2H, its C1-6 alkyl or aryl ester], acting against the effector phase of type IV allergy reactions, are prepared Thus, amidation of 4-(dimethylamino)cinnamic acid with N-[2-(dimethylamino)ethyl]-trans-4-methylcyclohexylamine in CH2Cl2 containing (EtO)2POCl, Et3N, and 4-(dimethylamino)pyridine gave N-[2-(dimethylamino)ethyl]-N-trans-4-methylcyclohexyl)-4-(dimethylamino)cinnamamide (III) which at 3.46 × 10-4 mol/kg p.o. inhibited 100% sheep red blood cell (SRBC)-induced allergy type IV reaction in legs of SRBC-sensitized mice. A tablet formulation containing III was described. A total of 251 cinnamic acid derivatives were prepared The experimental process involved the reaction of Methyl 1-methyl-4-oxocyclohexanecarboxylate(cas: 37480-41-4).Safety of Methyl 1-methyl-4-oxocyclohexanecarboxylate
The Article related to cinnamic acid preparation allergy inhibitor, cinnamamide preparation allergy inhibitor, type iv allergy reaction inhibitor, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Safety of Methyl 1-methyl-4-oxocyclohexanecarboxylate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics