On June 1, 1984, there was a patent about antitumor agents.COA of Formula: C10H11FO2 The title of the patent was Aromatic retinoids. And the patent contained the following:
Antineoplastic title compds I (R = alkoxy, OH; R1 = H, F; R2 = H, halo, OH, alkyl, alkoxy) were prepared by condensation of phosphonates II with β-ionone in the presence of LiN(CHMe2)2. Thus, 5.1 g II (R = OEt, R1 = F, R2 = H) in THF was added to a mixture of HN(CHMe2)2, hexane, and BuLi at -78° over 5 min, the resulting mixture allowed to react for 15 min, 4.8 g β-ionone in THF added at -78°, and the resulting mixture allowed to react at -78° for 30 min and then at room temperature overnight to give 2.69 g I (R = OEt, R1 = F, R2 = H). I inhibited trachea keratinization in hamsters and ornithine decarboxylase release induced by 12-O-tetradecanoylphorbol 13-acetate. The experimental process involved the reaction of Ethyl 3-fluoro-4-methylbenzoate(cas: 86239-00-1).COA of Formula: C10H11FO2
The Article related to aromatic retinoid antitumor, Terpenes and Terpenoids: Higher Terpenes and Miscellaneous Terpenoids, Including Carotenoids and Vitamins K and other aspects.COA of Formula: C10H11FO2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics