On August 13, 2020, Hwang, Jong Yeon; Ha, Jae Du; Cho, Sung Yun; Kim, Pilho; Yun, Chang Soo; Kim, Hyun Jin; Park, Sung Goo; Park, Byoung Chul; Kim, Jeong Hoon; Kim, Sunhong published a patent.SDS of cas: 882518-89-0 The title of the patent was Preparation of target protein EED degradation-inducing degraducer for preventing or treating diseases related to EED, EZH2, or PRC2. And the patent contained the following:
The present invention relates to a target protein degradation-inducing Degraducer, a preparation method thereof, and a pharmaceutical composition for preventing or treating diseases related to EED, EZH2, or PRC2 comprising same as an active ingredient. A novel compound ULB-L-PTM [PTM = EED targeting mols.; L = single bond, chem. linker; ULB = cereblon, MDM2, cIAP, VHL E3 ubiquitin ligase binder] is a Degraducer compound that induces degradation of a target protein, i.e., embryonic ectoderm development (EED) or polycomb repressive complex 2 (PRC2), utilizing cereblon E3 ubiquitin ligase, von Hippel-Lindau tumor suppressor (VHL) E3 ubiquitin ligase, mouse double minute 2 homolog (MDM2) E3 ubiquitin ligase, and cellular inhibitor of apoptosis protein 1 (cIAP) E3 ubiquitin ligase, wherein the compound has an aspect of remarkably achieving target protein degradation-inducing activity through a ubiquitin proteasome system (UPS), and therefore there is a useful effect in that it is possible to provide a pharmaceutical composition for preventing or treating diseases or conditions related to a target protein, and a functional health food composition for preventing or improving same, comprising said compound as an active ingredient. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).SDS of cas: 882518-89-0
The Article related to preparation target protein eed degradation inducing degraducer, eed ezh2 prc2 disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.SDS of cas: 882518-89-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics