On November 13, 2014, Guo, Xialing; Zhu, Zhen published a patent.Product Details of 53838-27-0 The title of the patent was Thienopyridine compounds as tyrosine kinase modulators and their preparation. And the patent contained the following:
The invention is directed to compounds of formula I that are potent tyrosine kinase modulators, and are suitable for the treatment and prevention of diseases and conditions related to abnormal activities of tyrosine kinase receptors. Compounds of formula I wherein X is NH and derivatives O, and SO0-3; n is 0 – 3; m is 0 – 2; R1 is H, halo, C1-8 alkyl, etc.; R2 is H, alkoxy, alkoxyalkoxy, alkyl, etc.; R3 is (un)substituted C1-5 alkyl, (un)branched C1-5 haloalkyl, C1-5 alkoxy, etc.; R4 is (un)substituted alkoxy, alkoxyalkyl, alkoxycarbonyl, etc.; Y is (CH2)0-3O(CH2)0-3, (CH2)0-4NH(CH2)0-3 and derivatives; (CH2)0-3CO(CH2)0-3, etc.; A and B are independently Ph, naphthyl, 5- to 6-membered heteroaryl, etc.; Z is (CH2)0-1NHCONH(CH)0-1 and derivatives, (CH2)0-1NHCSNH(CH)0-1 and derivatives, (CH2)0-1NHCO and derivatives, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by etherification of Me 7-bromothieno[3,2-b]pyridine-2-carboxylate with 4-aminophenol; the resulting Me 7-(4-aminophenoxy)thieno[3,2-b]pyridine-2-carboxylate underwent addition to 2-fluoro-5-methylphenyl isocyanate to give compound II. All the invention compounds were evaluated for their tyrosine kinase modulatory activity. From the assay, it was determined that compound II exhibited IC50 values in the range of 2 nM to 18 nM toward VEGFR2. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Product Details of 53838-27-0
The Article related to thienopyridine preparation tyrosine kinase modulator, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Product Details of 53838-27-0
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