On December 2, 1997, Gilbert, Kevin; Williams, Peter D.; Evans, Ben E.; Hobbs, Doug W.; Veber, Daniel F. published a patent.Related Products of 53838-27-0 The title of the patent was Preparation of hydantoin and succinimide-substituted derivatives of spiroindanylcamphorsulfonylamides for use as oxytocin and vasopressin antagonists. And the patent contained the following:
Camphorsulfonylamides I and II [R = heterocyclyl such as imidazolyl, pyrrolidinyl, piperidinyl, piperazinyl, maleimido; R1 = H; R1R1 = bond] were prepared as oxytocin and vasopressin antagonists useful in the treatment of preterm labor, dysmenorrhea, and for the stoppage of labor preparatory to Cesarean delivery. Thus, endo-I [R = maleimido, R1 = H] was prepared starting from bis(2-chloroethyl)amine dihydrochloride, indene, (+)-10-camphorsufonyl chloride, and maleic anhydride and showed 70% inhibition of specific binding at 1000 nM in the [3H]OT binding assay. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Related Products of 53838-27-0
The Article related to camphorsulfonylamide preparation oxytocin receptor antagonist, vasopressin receptor antagonist spiroindanylcamphorsulfonylamide preparation, Terpenes and Terpenoids: Monoterpenes (C10), Including Cannabinoids, Chrysanthemic Acids, and Iridoid Aglycons and other aspects.Related Products of 53838-27-0
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