On December 29, 1998, Duggan, Mark E.; Egbertson, Melissa S.; Hartman, George D.; Young, Steven D.; Ihle, Nathan C. published a patent.Safety of tert-Butyl (4-hydroxy-2-nitrophenyl)carbamate The title of the patent was Preparation of 4-[(4-piperazinobeznoyl)amino]phenyl(oxy)alkanoates as fibrinogen receptor antagonists. And the patent contained the following:
XYZAB [I; A = (un)substituted (hetero)arylene; B = O(CH2)mCO2R9, (CH2)nCO2R9, CHR8(CH2)pCO2R9, OCHR8(CH2)pCO2R9; R8 = H, OH, alkyl, alkoxy, aryl, etc.; R9 = H, (ar)alkyl, aryl, acylalkyl, etc.; X = (un)substituted heterocyclyl or -heteroaryl; Y = (un)substituted heterocyclylene or -(hetero)arylene; Z = bond, NH, CONH, CO, CH2CH2, etc.; m = 1-3; n,p = 0-3] were prepared Thus, 4-(H2N)C6H4CO2Me was cyclocondensed with HN(CH2CH2Cl)2 and the N-protected and saponified product amidated by 4-BrC6H4NH2 to give the bromobenzanilide which was condensed with CH2:CHCO2Me and the product converted in 3 addnl. steps to 4-RC6H4CONHC6H4(CH2CH2CO2H)-4 (R = piperazino). Data for biol. activity of I were given. The experimental process involved the reaction of tert-Butyl (4-hydroxy-2-nitrophenyl)carbamate(cas: 201811-20-3).Safety of tert-Butyl (4-hydroxy-2-nitrophenyl)carbamate
The Article related to piperazinobeznoylaminophenylalkanoate preparation fibrinogen receptor antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of tert-Butyl (4-hydroxy-2-nitrophenyl)carbamate
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