On August 15, 2016, Choliq, Azka Azkiya; Watanabe, Junya; Misaki, Tomonori; Okamoto, Yasuaki; Sugimura, Takashi published an article.HPLC of Formula: 3976-69-0 The title of the article was Enantioselective hydrogenation of β-aryl-β-ketoester over α-hydroxy acid-modified Raney nickel catalysts: competitive hydrogenation with methyl acetoacetate. And the article contained the following:
The enantioselective hydrogenation of the aromatic β-ketoesters, Me 3-phenyl-3-oxopropanoate (1) and its p-methoxy analog (2), was studied over tartaric acid-modified Raney nickel catalysts. A competitive hydrogenation approach was used to clarify the catalytic behaviors of the enantio-differentiating hydrogenation of aromatic β-ketoesters over tartaric acid-modified Raney nickel, malic acid-modified Raney nickel, and unmodified Raney nickel in comparison with aliphatic one, represented by Me acetoacetate. The authors found that the enantioselectivity could be elucidated by the interaction modes between the surface modifier, Ni metal surface, and the substrate as well as the keto/enol ratio of the substrate. The authors suggest that the moderate enantioselectivity of 1 over tartaric acid-modified Raney nickel is the result of distorted, weak two-point hydrogen bond interactions with surface tartrate due to unfavorable phenyl-Ni metal surface interactions. The p-methoxy group of 2 suppresses the phenyl-Ni metal surface interactions, resulting in an increase in the enantioselectivity of 2 over tartaric acid-modified Raney nickel. Ligand acceleration effects were observed with Me acetoacetate and 2 but not with 1. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).HPLC of Formula: 3976-69-0
The Article related to aryl keto ester enantioselective hydrogenation tartaric acid nickel catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.HPLC of Formula: 3976-69-0
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