On August 31, 2022, Cheng, Zao; Gao, Junfei; Liu, Qianqian; Gu, Qun published an article.Name: (R)-Methyl 3-hydroxybutanoate The title of the article was The effect of alkyl chain length of (R)-3-Hydroxybutyric alkyl ester on antibacterial activity and its antibacterial mechanism. And the article contained the following:
This work describes the relationship between the antibacterial activity and the ester chain length (C1-C8) of (R)-3-Hydroxybutyric ((R)-3-HB) alkyl esters that synthesized from (R)-3-HB acid ((R)-3-HBA) by esterification reaction. The min. inhibitory concentration (MIC) and min. bactericidal concentration (MBC) decrease as the length of the (R)-3-HB alkyl ester chain increases from 1 to 6, but (R)-3-HB-C7 and (R)-3-HB-C8 have their own rules for different microorganisms. Among them, the (R)-3HB-C6 has the relatively best antibacterial and antifungal properties, which MIC were 1.95 mg mL-1 against E. coli and S. aureus; 0.98 mg mL-1 against C. albicans and B. subtilis; 0.49 mg mL-1 against A. niger. Finally, the antimicrobial mechanisms of the (R)-3HB-C6 are revealed, and these include disruption of biofilm and the bacterial wall/membrane, leakage of the intracellular content, and change in the transmembrane potential. These results imply the potential application of (R)-3-HB alkyl ester as new antimicrobial agents; future research can use this as an antibacterial element to synthesize new polymer materials or agents with high-efficiency antibacterial activity. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Name: (R)-Methyl 3-hydroxybutanoate
The Article related to hydroxybutyric alkyl ester chain length antibacterial activity mechanism, antibacterial mechanism, antimicrobials agents, chain length, esterification, polyhydroxyalkanoates and other aspects.Name: (R)-Methyl 3-hydroxybutanoate
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