On June 9, 2016, Chen, Austin; Bravo, Yalda; Stock, Nicholas; Pedram, Bijan; Jacintho, Jason; Clark, Ryan C.; Truong, Yen published a patent.Application of 37480-41-4 The title of the patent was Thio-substituted benzamides as antiviral agents for the treatment of treatment HBV infection and their preparation. And the patent contained the following:
The invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of formula I. Compounds of formula I wherein each R1, R2, and R3 are halo; R4 is (un)substituted C3-7 cycloalkyl (un)substituted C1-6 alkyl-C3-7 cycloalkyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by thioetherification of N-(3,4,5-trifluoromethylphenyl)-4-fluoro-3-iodobenzamide with 1-(mercaptomethyl)cyclopropylacetic acid. The invention compounds were evaluated for their antiviral activity (some data given). The experimental process involved the reaction of Methyl 1-methyl-4-oxocyclohexanecarboxylate(cas: 37480-41-4).Application of 37480-41-4
The Article related to thiobenzamide preparation antiviral treatment hbv infection, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Application of 37480-41-4
Referemce:
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