On April 22, 1999, Cameron, Kimberly O’Keefe; Lefker, Bruce Allen; Rosati, Robert Louis published a patent.Electric Literature of 142327-44-4 The title of the patent was Preparation of prostaglandin agonists and their use to treat bone disorders. And the patent contained the following:
Title prostaglandin agonists GAB(KM)QZ [A is SO2, CO; G is Ar, alkylene, ArCONHalkylene, amino, oxyalkylene, etc.; B is N, CH; Q is alkylene, alkyl, alkylene-W-alkylene, alkylene-W-X-alkylene; W is oxy, thio, sulfino, sulfonyl, aminosulfonyl, etc.; X is aryl; K is a bond, alkylene, thioalkylene, alkylenethioalkylene, etc.; M is Ar, ArSar, ArSOAr, ArSO2Ar, ArOAr], prodrugs thereof and the pharmaceutically acceptable salts of said compounds and said prodrugs are prepared as well as methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists are discussed. The prostaglandin agonists are useful for the treatment of bone disorders including osteoporosis. The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Electric Literature of 142327-44-4
The Article related to arylsulfonylaminoaliphaticcaboxylic acid preparation prostaglandin agonist, arylsulfonylaminoaromaticcaboxylic acid preparation prostaglandin agonist, Aliphatic Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Electric Literature of 142327-44-4
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