On April 15, 2015, Yamashita, Hiroko; Demizu, Yosuke; Misawa, Takashi; Shoda, Takuji; Kurihara, Masaaki published an article.Application In Synthesis of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate The title of the article was Synthesis of a bis-cationic α,α-disubstituted amino acid (9-amino-bispidine-9-carboxylic acid) and its effects on the conformational properties of peptides. And the article contained the following:
A new bis-cationic cyclic amino acid, 9-amino-3,7-diazabicyclo[3.3.1]nonane-9-carboxylic acid (9-amino-bispidine-9-carboxylic acid = Abp), which is available for both solution phase and solid phase peptide synthesis, was designed and synthesized. Furthermore, a heterotripeptide Cbz-Leu-Abp-Ala-OMe containing Abp was prepared, and its dominant conformation was analyzed by examining its NMR and IR spectra and performing mol. modeling. The tripeptide Cbz-Leu-Abp-Ala-OMe formed a β-turn structure as its preferred conformation in solution The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Application In Synthesis of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate
The Article related to peptide amino bispidine synthesis conformation nmr ir, amino acid disubstituted amino bispidine synthesis, piperidone cyclocondensation benzylamine paraformaldehyde hydantoin bucherer berg cyclization, hydrolysis protection peptide coupling conformation mol modeling and other aspects.Application In Synthesis of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate
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