On March 31, 2020, Yakovenko, Georgiy G.; Lukianov, Oleh A.; Yagodkina-Yakovenko, Marta S.; Bol’but, Andriy V.; Vovk, Mikhailo V. published an article.Category: esters-buliding-blocks The title of the article was Synthesis of 5-amino-1H-pyrazolo[4,3-b]pyridine derivatives and annulation of imidazole and pyrimidine rings thereto. And the article contained the following:
A series of 5-amino-1H-pyrazolo[4,3-b]pyridine derivatives I [R1 = Me, Et, Ph, etc.; R2 = H, OMe; R3 = CN, C(O)NH2, CO2tBu] was synthesized via Friedlander reaction of N-Boc-protected 1-alkyl(aryl)-5-formyl-1Hpyrazol-4-amines with alkyl nitriles. Cyclocondensation of some of the compounds I with orthoesters, Et oxalyl chloride or carbonyldiimidazole to afford pyrazolo[3′,4′,5,6]pyrido[2,3-d]pyrimidine derivatives II [R4 = Me, tBu, Ph; R5 = H, iPr, Ph] and III [R1 = Me, Et, Ph, etc.] was reported. Cyclocondensation of some of the compounds I with chloroacetaldehyde, bromotrifluoroacetone or Et bromopyruvate to form imidazo[1,2-a]pyrazolo[3,4-e]pyridines IV [R6 = Me, Et, tBu, Ph; R2 = H, OMe; R7 = CN, C(O)NH2; R8 = H, CO2Et, CF3] was reported. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Category: esters-buliding-blocks
The Article related to amino pyrazolopyridine preparation, formyl pyrazole amine alkyl nitrile friedlander, imidazopyrazolopyridine preparation, carbonyl halide amino pyrazolopyridine cyclocondensation, pyrazolopyridopyrimidine preparation and other aspects.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics