On April 15, 2018, Xu, Yangyang; Cai, Hao; Cao, Gang; Duan, Yu; Pei, Ke; Tu, Sicong; Zhou, Jia; Xie, Li; Sun, Dongdong; Zhao, Jiayu; Liu, Jing; Wang, Xiaoqi; Shen, Lin published an article.Product Details of 85-91-6 The title of the article was Profiling and analysis of multiple constituents in Baizhu Shaoyao San before and after processing by stir-frying using UHPLC/Q-TOF-MS/MS coupled with multivariate statistical analysis. And the article contained the following:
Baizhu Shaoyao San (BSS) is a famous traditional Chinese medicinal formula widely used for the treatment of painful diarrhea, intestinal inflammation, and diarrhea-predominant irritable bowel syndrome. According to clin. medication, three medicinal herbs (Atractylodis Macrocephalae Rhizoma, Paeoniae Radix Alba, and Citri Reticulatae Pericarpium) included in BSS must be processed using some specific methods of stir-frying. On the basis of the classical theories of traditional Chinese medicine, the therapeutic effects of BSS would be significantly enhanced after processing. Generally, the changes of curative effects mainly result from the variations of inside chem. basis caused by the processing procedure. To find out the corresponding changes of chem. compositions in BSS after processing and to elucidate the material basis of the changed curative effects, an optimized ultra-high-performance liquid chromatog.-quadrupole/time-of-flight mass spectrometry in pos. and neg. ion modes coupled with multivariate statistical analyses were developed. As a result, a total of 186 compounds were ultimately identified in crude and processed BSS, in which 62 marker compounds with significant differences between crude and processed BSS were found by principal component anal. and t-test. Compared with crude BSS, the contents of 23 compounds were remarkably decreased and the contents of 39 compounds showed notable increase in processed BSS. The transformation mechanisms of some changed compounds were appropriately inferred from the results. Furthermore, compounds with extremely significant differences might strengthen the effects of the whole herbal formula. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Product Details of 85-91-6
The Article related to baizhu shaoyao san constituent stir frying uhplc qtof ms, baizhu shaoyao san, chemical markers, multivariate statistical analysis, traditional chinese herbal formula, traditional chinese medicine processing, uhplc/q-tof-ms/ms and other aspects.Product Details of 85-91-6
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