On January 15, 2019, Wu, Ren-Jun; Ren, Tongtong; Gao, Jie-Yu; Wang, Li; Yu, Qilin; Yao, Zheng; Song, Guo-Qing; Ruan, Wei-Bin; Niu, Cong-Wei; Song, Fu-Hang; Zhang, Li-Xin; Li, Mingchun; Wang, Jian-Guo published an article.Formula: C13H10O3 The title of the article was Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. And the article contained the following:
A novel synthesis of 68 ethoxysulfulron (ES) derivatives I [R1 = 2-NO2, 2-COOMe, 2-I(CH2)2O, etc.; R2 = Me, MeO, Cl, Br, I; R3 = Me, MeO] and evaluation of their inhibition constants (Ki) against C. albicans AHAS and cell based min. inhibitory concentration (MIC) values were discussed. The target compounds I [R1 = 2-COOEt; R2 = Me, MeO, Cl, Br, I; R3 = MeO] displayed stronger AHAS inhibitions than ES did. Compound I [R1 = 2-COOEt, R2 = MeO, R3 = MeO] had the best Ki of 6.7 nM against fungal AHAS and MIC values of 2.5 mg/L against Candida albicans and Candida parapsilosis after 72 h. A suitable nematode model was established here and the antifungal activity of compound I [R1 = 2-COOEt, R2 = MeO, R3 = MeO] was further evaluated in-vivo. A possible binding mode was simulated via mol. docking and a comparative field anal. (CoMFA) model was constructed to understand the structure-activity relationship. The current study had indicated that some ES derivatives should be considered as promising hits to develop antifungal drugs with novel biol. target. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Formula: C13H10O3
The Article related to phenyl pyrimidinylcarbamoylsulfamate preparation antifungal acetohydroxyacid synthase inhibition sar docking, acetohydroxyacid synthase, antifungal agents, enzyme inhibition, ethoxysulfuron derivative, nematode model and other aspects.Formula: C13H10O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics