On September 2, 2022, Wang, Zongkang; Yin, Liqiang; Wang, Mengdan; Zhu, Yilin; Yang, Yajie; Cheng, Lu; Wang, Chengyu; Li, Yanzhong published an article.Category: esters-buliding-blocks The title of the article was Selective C-O Bond Forming Reactions at Indole-C2-Position toward Polycyclic Indolone or Indolinone Derivatives Tethered with Medium-Sized Rings. And the article contained the following:
A methodol. involving the chemoselective synthesis of tetracyclic [1,3]oxazino[3,2-a]indol-4-ones I [R1 = H, 2-F, 3-Br, 1-MeO, 2-MeO; R2 = Ph, 4-FC6H4, 3-ClC6H4, etc.; R3 = CN, CO2Me, CO2Et, X = (CH2)n; n = 1, 2, 3] or tetracyclic [1,3]oxazino[3,2-a]indoline-4-ones II [R4 = Ph, 3-ClC6H4, 4-BrC6H4, etc.; R5 = CN, CO2Me, CO2Et; R6 = H, 2-F, 3-Br, 2-MeO] tethered with a medium-sized ring by cross dehydrogenative coupling (CDC) or nucleophilic addition (NA) reaction had been developed. [1,3]Oxazino[3,2-a]indol-4-one compounds fused with a medium-sized ring were constructed through a CDC reaction in the presence of I2 and K2CO3. Whereas, [1,3]oxazino[3,2-a]indoline-4-ones tethered with a medium-sized ring were obtained with a TfOH system by NA reaction. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Category: esters-buliding-blocks
The Article related to tetracyclic oxazinoindolone chemoselective preparation, oxazinoindolinone tetracyclic chemoselective preparation, hydroxycycloheptadienyl indolyl methanone cross dehydrogenative coupling nucleophilic addition and other aspects.Category: esters-buliding-blocks
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