On August 31, 2020, Thakur, Kratima; Khare, Naveen K. published an article.Quality Control of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate The title of the article was Copper mediated A3-coupling reaction for the preparation of enantioselective deoxy sugar based chiral propargylamine using bifunctional ligand L-proline. And the article contained the following:
An efficient three component coupling of aromatic aldehyde, deoxy sugar based alkyne (α-2-deoxy propargyl glycoside) and heterocyclic amine have been refluxed to synthesize stereoselective chiral propargylamine with good to excellent yield using only CuI catalyst along with bifunctional ligand L-proline. This method has proved to be applicable in wide range of substrates and found highly enantioselective with respect to earlier reported methods. In addition, L-proline was found as a chiral source which demonstrated that it could be developed as a highly enantioselective method for the construction of deoxy sugar based chiral propargylamine. The ligand L-proline was used for the first time in enantioselective A3-coupling reaction of α-2-deoxy propargyl glycosides involving substituted aromatic aldehyde and heterocyclic amines. Herein, we have synthesized 15 novel compounds based on A3-coupling reaction and structures of all the enantioselective compounds were characterized by TLC and NMR spectroscopy. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Quality Control of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate
The Article related to glycoside propargylamine proline copper catalyst coupling preparation aldehyde, copper catalyst coupling preparation enantioselective deoxy sugar propargylamine proline, a(3)-coupling reaction, c–h bond activation, enantioselectivity, propargylamines, l-proline and other aspects.Quality Control of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate
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