On October 1, 2019, Thakur, Kratima; Khare, Naveen K. published an article.Synthetic Route of 2873-29-2 The title of the article was Synthesis of glycoconjugate mimics by ‘click chemistry’. And the article contained the following:
Stereo-defined 2-deoxy propargyl glycosides can be used for the synthesis of corresponding 1,4-disubstituted sugar derived triazoles by using only CuI and stereo-defined sugar azide derivatives The click chem. which involves copper (I) catalyzed alkyne-azide 1,3-dipolar cycloaddition, was used to prepare a library of glycoconjugates mimics. Different sugar propargyl-2-deoxy-O-α-D-glycopyranoside derivatives and β-glycopyranosyl azide derivatives were coupled using catalyst CuI to yield triazole glycoconjugates. The catalyst CuI (2.5 equivalent) in CH3CN was found to be most efficient for the synthesis of 1,4-disubstituted triazole scaffolds affording up to 94% of optimized yield and with retention of the anomeric configuration of the starting glycosides. The key feature of this methodol. is the absence of sodium L-ascorbate/ascorbic acid which is most active substrate of current research with strong potential for click reactions. In this article, the library of novel stereoselective deoxy sugar derived triazole glycoconjugates have been synthesized and structures were determined by the 1H, 13C & 2D NMR spectroscopy. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Synthetic Route of 2873-29-2
The Article related to click alkyne azide triazole cycloaddition catalyst preparation, triazole glycoconjugate preparation stereoselective library mol structure, 1,3-dipolar cycloaddition, click reaction, cui, glycoconjugates, stereoselectivity and other aspects.Synthetic Route of 2873-29-2
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