On June 21, 2017, Taylor, Nicholas J.; Emer, Enrico; Preshlock, Sean; Schedler, Michael; Tredwell, Matthew; Verhoog, Stefan; Mercier, Joel; Genicot, Christophe; Gouverneur, Veronique published an article.Name: (Trimethoxymethyl)benzene The title of the article was Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands. And the article contained the following:
The compatibility of various heterocycles, particularly nitrogen heterocycles, towards the copper-mediated 18F-fluorination of aryl pinacolboronates with 18F-fluoride was determined using fluorination reactions of a model substrate in the presence of exogenous heterocycles and the fluorination reactions of substrates possessing heterocycles with fluorination on an attached aromatic ring or directly attached to the heterocycle of interest. Using this information, syntheses of seven 18F-labeled structurally complex pharmaceutically relevant heterocycle-containing mols. were designed and executed. The method may be useful in designing syntheses of other radiolabeled compounds and delineating the scope of utility of other radiolabeling methods. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Name: (Trimethoxymethyl)benzene
The Article related to robustness screen copper catalyzed radiofluorination, chemoselectivity copper catalyzed radiofluorination arylpinacolboronate attached unattached heterocycle, radiofluorinated pet mol synthetic design and other aspects.Name: (Trimethoxymethyl)benzene
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