On June 30, 1999, Stohlmeyer, Michelle M.; Tanaka, Hiroko; Wandless, Thomas J. published an article.Computed Properties of 59524-07-1 The title of the article was A Stereospecific elimination to form dehydroamino acids: synthesis of the phomopsin tripeptide side chain. And the article contained the following:
The authors have developed an efficient and stereospecific method to synthesize trisubstituted and tetrasubstituted α,β-dehydroamino acids from β-hydroxyamino acid derivatives For example, β-hydroxyamino acid I is reacted with SOCl2 in CH2Cl2 to give the sulfamidite II in 100% yield; next, DBU is added to II in CH2Cl2 to give the cis-dehydroamino acid III in 91% yield. The tripeptide side chain of phomopsin was synthesized using this method. The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).Computed Properties of 59524-07-1
The Article related to amino acid dehydro synthesis hydroxyamino acid precursor, sulfamidite intermediate preparation hydroxyamino acid reaction thionyl chloride, elimination stereospecific dbu reaction sulfamidite key step, phomopsin tripeptide side chain synthesis and other aspects.Computed Properties of 59524-07-1
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