On October 15, 2007, Ramesh, Ramapanicker; De, Kavita; Chandrasekaran, Srinivasan published an article.SDS of cas: 59524-07-1 The title of the article was An efficient synthesis of dehydroamino acids and dehydropeptides from O-Cbz and O-Eoc derivatives of serine and threonine. And the article contained the following:
A simple and efficient method for the synthesis of dehydroamino acids from serine and threonine is reported. Various O-Cbz and O-Eoc derivatives of serine and threonine are prepared using CbzCl (PhCH2OCOCl) and EocCl (EtOCOCl) , resp., and are subjected to an anti-selective elimination on treatment with K2CO3 in DMF at 65° to afford dehydroalanine and dehydroaminobutyric acid derivatives, resp., in excellent yields. The high stability of these carbonate derivatives of serine and threonine allows their use in normal peptide synthesis as protected serine and threonine residues. Peptides synthesized by incorporating O-Cbz or O-Eoc derivatives undergo ready elimination under the reported conditions, to give the corresponding dehydropeptides in excellent yields. The reaction conditions are mild enough not to cause the racemization of other stereogenic centers present in the peptide. The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).SDS of cas: 59524-07-1
The Article related to dehydroamino acid preparation cbz eoc protected serine threonine, dehydropeptide preparation cbz eoc protected serine threonine, anti beta elimination reaction cbz eoc protected serine threonine and other aspects.SDS of cas: 59524-07-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics