On November 30, 2017, Radulovic, Niko S.; Miltojevic, Ana B.; Stojanovic, Nikola M.; Randjelovic, Pavle J. published an article.Name: Methyl N-Methylanthranilate The title of the article was Distinct urinary metabolite profiles of two pharmacologically active n-methylanthranilates: three approaches to xenobiotic metabolite identification. And the article contained the following:
Two volatile alkaloids, iso-Pr N-methylanthranilate (IMA) and Me N-methylanthranilate (MMA), present in the human diet and cosmetic products, were recently demonstrated to possess important pharmacol. activities. While MMA is considered to be phototoxic, there is scarce data on the toxicity of IMA. Herein, we analyzed urinary metabolites of IMA and MMA in rats (200 mg kg-1, i.p., 7 days) by combining three different approaches: 1) preparative chromatog., 2) synthesis, and 3) SPR. The preparative approach, Sephadex LH-20 chromatog. of the extract of urine samples of IMA treated animals, in conjunction with NMR, enabled the identification of 16 different anthranilate derivatives, among which products of aromatic core hydroxylation (iso-Pr 5-hydroxy-N-methylanthranilate, iso-Pr 5-hydroxyantranilate, iso-Pr 3-hydroxyantranilate) were the major ones. The first application of the synthetic/combinatorial approach led to a successful identification of MMA metabolites, where 2-(methylamino)benzamide and N-methylanthranilic acid were the principal ones, among 14 others. Generally, MMA and IMA undergo analogous biotransformation pathways; however, MMA predominantly underwent chem. conversions of the ester group, i.e. transformation into derivatives of anthranilamide and anthranilic acid, while the major metabolic pathway of IMA was hydroxylation of the aromatic core. Addnl., pathohistol. examinations revealed no signs of liver toxicity, or other signs of toxicity. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Name: Methyl N-Methylanthranilate
The Article related to urinary metabolite isopropyl methyl n methylanthranilate, isopropyl n-methylanthranilate, metabolite identification, methyl n-methylanthranilate, rat, urinary metabolites, xenobiotic and other aspects.Name: Methyl N-Methylanthranilate
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