On March 12, 1998, Picard, Joseph Armand; Sliskovic, Drago Robert published a patent.Computed Properties of 53838-27-0 The title of the patent was Preparation of dibenzofuransulfonyl and related amino acids for inhibition of matrix metalloproteinases. And the patent contained the following:
Heterocyclyl sulfonyl amino acids I (R = unnatural amino acid; X = O, S, SO, SO2, CO, NH, alkyl- or alkylphenylimino; R1, R2 = H, alkyl, Ph, NO2, halo, alkoxy, CN, etc.) or their pharmaceutically acceptable salts, esters, amides, and prodrugs were prepared as matrix metalloproteinases inhibitors. Thus, 6-[2-(4-chlorophenoxy)-2-methylpropionylamino]-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid, prepared by acylation of 6-amino-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Me ester hydrobromide, showed IC50 >100 μM against MMP-1 and MMP-7. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Computed Properties of 53838-27-0
The Article related to amino acid dibenzofuransulfonyl dibenzothiophenesulfonyl preparation activity, dibenzofuransulfonyl amino acid preparation inhibitor metalloproteinase, dibenzothiophenesulfonyl amino acid preparation inhibitor metalloproteinase and other aspects.Computed Properties of 53838-27-0
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