On July 17, 2020, Nagai, Takuya; Mimata, Nao; Terada, Yoshihiro; Sebe, Chikayoshi; Shigehisa, Hiroki published an article.Formula: C12H14F3NO2 The title of the article was Catalytic Dealkylative Synthesis of Cyclic Carbamates and Ureas via Hydrogen Atom Transfer and Radical-Polar Crossover. And the article contained the following:
Guided by the transition metal hydrogen atom transfer and radical-polar crossover concepts, a functional-group tolerant and scalable method for the synthesis of cyclic carbamates and ureas I [R1 = Ph, 4-ClC6H4, 4-MeCOC6H4CH2, etc.; R2 = H, Me; X = O, NTs, NNs; n = 1,2,3,4], which were found in the structures of bioactive compounds was developed. This method not only provided common five-membered ring but also six-to-eight-membered ring products. The reaction proceeded through the intramol. displacement of an alkylcobalt(IV) intermediate and dealkylation by 2,4,6-collidine, the activation energies of these steps were calculated by DFT. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Formula: C12H14F3NO2
The Article related to cyclic carbamate preparation, alkenyl carbamate dealkylative hydrogen transfer crossover cobalt complex catalyst, urea cyclic preparation, isourea alkenyl dealkylative hydrogen transfer crossover cobalt complex catalyst and other aspects.Formula: C12H14F3NO2
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