On June 30, 2019, Miltojevic, Ana B.; Stojanovic, Nikola M.; Randjelovic, Pavle J.; Radulovic, Niko S. published an article.COA of Formula: C9H11NO2 The title of the article was Distribution of methyl and isopropyl N-methylanthranilates and their metabolites in organs of rats treated with these two essential-oil constituents. And the article contained the following:
Two volatile alkaloids, Me (MMA) and iso-Pr N-methylanthranilates (IMA), identified in the essential oil of Choisya ternata Kunth (Rutaceae), have been proven to possess polypharmacol. properties (antinociceptive, anti-inflammatory, gastro-, hepato-, nephroprotective activities, anxiolytic and antidepressant properties, and likewise an effect on diazepam-induced sleep). In the continuation of our investigation of their urinary-metabolite profiles, we performed GC-MS analyses of the diethyl-ether extracts of selected tissues (liver, kidneys, heart, brain, lungs, quadriceps femoris muscle, and spleen) of rats i.p. treated with MMA or IMA (2 g kg-1). Organ-metabolite profiles of MMA and IMA were qual. mutually analogous (varying only in the alc. moiety of the metabolites), and generally analogous to their urinary-metabolite profiles. The principal anthranilate-related compounds in the organs of rats treated with MMA, among 12 detected, were the products of ester hydrolysis, N-methylanthranilic and anthranilic acids. In the tissues of IMA-treated rats, among 16 compounds, the most abundant ones were the unmetabolized IMA and N-methylanthranilic acid. A collection of the compositional data regarding the anthranilate-related metabolites was statistically treated by multivariate statistical anal. that provided a better insight into the possible biotransformation pathways. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).COA of Formula: C9H11NO2
The Article related to choisya essential oil methyl isopropyl n methylanthranilate organ distribution, isopropyl n-methylanthranilate, metabolite identification, methyl n-methylanthranilate, multivariate statistical analysis, organs distribution, xenobiotic and other aspects.COA of Formula: C9H11NO2
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