On August 16, 2021, Liu, Xigong; Zhao, Changyin; Zhu, Rongxiu; Liu, Lei published an article.Product Details of 10472-24-9 The title of the article was Construction of Vicinal Quaternary Carbon Stereocenters Through Diastereo- and Enantioselective Oxidative 1,6-Conjugate Addition. And the article contained the following:
The asym. construction of vicinal quaternary carbon stereocenters with at least one moiety in acyclic systems is a formidable challenge. A solution involving diastereo- and enantioselective oxidative 1,6-conjugate addn was disclosed. The practical asym. cross-dehydrogenative coupling of 2,2-diarylacetonitriles and diverse α-substituted cyclic 1,3-dicarbonyls proceeds, for vicinal quaternary carbon stereocenters with one center in acyclic systems, in excellent yields and stereoselectivities. The generality of the approach was further demonstrated by the stereoselective creation of vicinal quaternary carbon stereocenters with both centers in acyclic systems using acyclic β-ketoesters as coupling partners. Computational studies elucidate the origins of both diastereo- and enantioselectivity. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Product Details of 10472-24-9
The Article related to diarylacetonitrile keto ester copper catalyst enantioselective oxidative conjugate addition, diaryl cyanomethyl alkanone carboxylate preparation, 1,6-conjugate addition, asymmetric catalysis, cross-dehydrogenative coupling, synthetic methods, vicinal quaternary stereocenters and other aspects.Product Details of 10472-24-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics