On April 30, 2022, Li, Zhi-Bin; Shi, Li-Ying; Han, Yu-Shuai; Chen, Jing; Zhang, Shan-Qiang; Chen, Jia-Xi; Liu, Jun; Tu, Hui-Hui; Lu, Qi-Qi; Yu, Yi; Jiang, Ting-Ting; Li, Ji-Cheng published an article.COA of Formula: C12H18O5 The title of the article was Pyridoxal phosphate, pyridoxamine phosphate, and folic acid based on ceRNA regulatory network as potential biomarkers for the diagnosis of pulmonary tuberculosis. And the article contained the following:
Pulmonary tuberculosis (TB) is a serious disease burden worldwide, and its effective early diagnosis is still facing challenges. Knowledge, acquired from multi-omics integration anal. about the association between different types of differentially expressed mols. in the plasma of TB patients and the disease traits, is anticipated to improve the accuracy of TB diagnosis through the ′′integrative pattern′′. In this study, the lncRNA-miRNA-mRNA interaction network was constructed based on the competing endogenous RNA (ceRNA) hypothesis by integrating our previous data sets of lncRNA, mRNA, miRNA, and metabolites. Moreover, the key regulatory axis was established by co-expression anal. and verified at the level of metabolites. A ceRNA regulatory network consisting of 23 lncRNAs, 10 miRNAs, and 113 mRNAs was constructed. The anal. results suggested that lncRNA (OSBPL10-AS1), miRNA (has-miR-485-5p), and mRNA (SLC23A2) might be involved in the regulation of vitamin metabolism in patients with TB. Metabolite anal. showed that compared with the normal control group, TB patients had abnormal vitamin metabolism, and the expression levels of pyridoxal phosphate, pyridoxamine phosphate, and folic acid were significantly different between the two groups (p < 0.05). Integrated multi-omics anal. showed that vitamin metabolism disorder may be one of the pathol. characteristic of TB. OSBPL10-AS1, hsa-miR-485-5p, SLC23A2, pyridoxal phosphate, pyridoxamine phosphate, and folic acid may collectively constitute the ′′integrative pattern′′ of multiple biomarkers, which may provide an accurate diagnosis of TB. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).COA of Formula: C12H18O5
The Article related to pyridoxamine pyridoxal phosphate folic acid pulmonary tuberculosis diagnosis, cerna regulatory network biomarker potential, biomarkers, metabolomics, pulmonary tuberculosis, transcriptomics, vitamins, cerna and other aspects.COA of Formula: C12H18O5
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