Kleinbeck, Florian; Fettes, Gabriela J.; Fader, Lee D.; Carreira, Erick M. published an article in 2012, the title of the article was Total Synthesis of Bafilomycin A1.SDS of cas: 3976-69-0 And the article contains the following content:
A convergent synthesis of bafilomycin A1 (I), a potent inhibitor of V-type ATPases, is presented. The synthesis relies on the zinc triflate mediated diastereoselective addition of a complex enyne to a sensitive aldehyde as the key fragment coupling. A ruthenium-catalyzed trans-reduction of the resulting propargylic enyne efficiently installs the required C10-C13 trans,trans-diene subunit, implementing an alternative strategy to traditional palladium-catalyzed cross-coupling strategies. A highly selective oxidation of a secondary hydroxyl group in a triol sets the stage for the completion of the synthesis. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).SDS of cas: 3976-69-0
The Article related to bafilomycin a1 stereoselective synthesis diastereoselective addition, reduction ruthenium catalyst stereoselective synthesis bafilomycin a1, oxidation selective stereoselective synthesis bafilomycin a1 and other aspects.SDS of cas: 3976-69-0
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