Huang, Wanqiao; Zhang, Ruzhong; Zhang, Ruxue; Yu, Jianxin; Wang, Mang published an article in 2022, the title of the article was Radical hydrotrifluoromethylation of ynamides: a route toward β-CF3 enamides.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate And the article contains the following content:
Radical hydrotrifluoromethylation of ynamides RNR2CCR1 (R = Ph, 3-chlorophenyl, benzodioxol-5-yl, etc.; R1 = H, cyclopropyl, Ph, etc.; R2 = Boc, Ac, Cbz) to provide an alternative route toward (E)-β-CF3 enamides RNR2CH=C(CF3)R1 was reported. By using PhICF3Cl as the CF3 reagent and DMF as the H-donor, the reaction occurred smoothly in the presence of NaH at room temperature Further reduction of the resulting β-CF3 enamides efficiently delivered β-CF3 amines RNHCH2CH(CF3)R1. Gram-scale synthesis was conducted to demonstrate the practicability of the method. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate
The Article related to aryl trifluoromethyl amine preparation, trifluoromethyl enamide preparation diastereoselective deprotection reduction reaction, ynamide chlorophenyl trifluoromethyliodane radical hydrotrifluoromethylation reaction and other aspects.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate
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