Huang, Rong; Li, Zhihong; Ren, Peiling; Chen, Wenzhang; Kuang, Yuanyuan; Chen, Jiakang; Zhan, Yuexiong; Chen, Hongli; Jiang, Biao published an article in 2018, the title of the article was N-phenyl-N-aceto-vinylsulfonamides as efficient and chemoselective handles for N-terminal modification of peptides and proteins.COA of Formula: C9H11NO2 And the article contains the following content:
A number of vinylsulfonamides were synthesized and screened to identify reagents that can be used to modify octreotide under biol. pH and room temperature with improved efficiency. N-Phenyl-N-aceto-vinylsulfonamide exhibits higher reactivity and has emerged as an efficient reagent that has the ability to realize the selective modification of peptides and proteins at the N-terminus via aza-Michael addition We showed that, after conjugation of peptides and proteins with the reagent containing a bioorthogonal functional group, the derivatives could be further labeled by functionalities, including fluorescent tags, modified drugs and polyethylene glycol (PEG) polymers without the need for prior treatment. Somatostatin, lysozyme, and RNaseA were selectively modified at the N-terminus, which illustrated the application of the method. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).COA of Formula: C9H11NO2
The Article related to phenyl aceto vinyl sulfonamide synthesis handle peptide protein modification, somatostatin lysozyme rnasea aza michael addition vinylsulfonamide regioselective synthesis, lysozyme rnasea click chem azide alkyne cycloaddition fluorescein and other aspects.COA of Formula: C9H11NO2
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