On December 12, 2008, Dragovich, Peter S.; Murphy, Douglas E.; Dao, Kimkim; Kim, Sun Hee; Li, Lian-Sheng; Ruebsam, Frank; Sun, Zhongxiang; Tran, Chinh V.; Xiang, Alan X.; Zhou, Yuefen published an article.Application of 119993-56-5 The title of the article was Efficient synthesis of (1R,2S) and (1S,2R)-2-aminocyclopentanecarboxylic acid ethyl ester derivatives in enantiomerically pure form. And the article contained the following:
A 4-step synthesis of an optically active synthetic intermediate [(1R,2S)-2-(4′-fluorobenzylamino)cyclopentanecarboxylic acid Et ester complex with (S)-(+)-mandelic acid (I), >99% de] required for the preparation of a promising HCV NS5B polymerase inhibitor is reported. This process utilizes mandelic acid as a resolving agent, which can be recovered in good yield by a simple extraction An optimized version of the chem. described avoids the use of chromatog. purifications making it suitable for large-scale applications. In addition, the straightforward conversion of compound I to enantiomerically pure (1R,2S)-2-aminocyclopentanecarboxylic acid Et ester and the corresponding Boc and Cbz derivatives (Boc = tert-butoxycarbonyl, Cbz = benzyloxycarbonyl) is reported. The preparation of the enantiomer of I, compound (II), in enantiomerically pure form and the conversion of this entity to (1S,2R)-2-aminocyclopentanecarboxylic acid Et ester and the corresponding Boc and Cbz derivatives is also described. The experimental process involved the reaction of Ethyl 2-aminocyclopentanecarboxylate hydrochloride(cas: 119993-56-5).Application of 119993-56-5
The Article related to enantiopure amino cyclopentanecarboxylic acid ethyl complex mandelic acid synthesis, aminocyclopentanecarboxylic acid ethyl ester hcv ns5b polymerase inhibitor preparation, mandelic acid resolving agent extraction hydrogenation and other aspects.Application of 119993-56-5
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