On April 3, 2015, Dikshit, Dinesh Kumar; Kumar, K. S. Anil; Dikshit, Madhu; Barthwal, Manoj Kumar; Misra, Ankita; Jain, Manish published a patent.Safety of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate The title of the patent was Preparation of 3,7-diazabicyclo[3.3.1]nonane carboxamides as antithrombotic agents. And the patent contained the following:
The present invention relates to the 3,7-diazabicyclo[3.3.1]nonane carboxamides of formula I as anti-thrombotic (anti-platelet) agents and process for preparation thereof. The invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors both in vitro and in vivo. Compounds of formula I wherein R’ is II and III; R is alkyl, acyl, tosyl, etc; R” is halo, cyano, lower alkyl, etc.; R1 is H and lower alkyl; R2 is lower alkyl and aryl; R3 is tert-butyloxycarbonyl and benzyloxycarbonyl groups; are claimed. Example compound IV was prepared by acylation of N-Bocbispidine with N-benzylpyroglutamic acid. The invention compounds were evaluated for their antithrombotic activity (some data given). The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Safety of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate
The Article related to preparation pyroglutamyldiazabicyclononane carboxamide antithrombotic, collagen induced platelet adhesion aggregation inhibitor preparation pyroglutamyldiazabicyclononane carboxamide and other aspects.Safety of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate
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