On January 31, 2018, Cao, Shi-Xuan; Wang, Jia-Xi; He, Zheng-Jie published an article.Category: esters-buliding-blocks The title of the article was Magnetic nanoparticles supported cinchona alkaloids for asymmetric Michael addition reaction of 1,3-dicarbonyls and maleimides. And the article contained the following:
Magnetic nanoparticles Fe3O4@SiO2 supported cinchona alkaloids (quinine and quinidine) were successfully synthesized as magnetically recoverable organocatalysts and characterized by FT-IR, XPS, SEM measurements, and elemental anal. Their catalytic activity and stereoselectivity were preliminarily evaluated in the asym. Michael addition reaction of 1,3-dicarbonyl compounds and maleimides to afford 3-(2-oxocyclopentyl)pyrrolidine-2,5-dione derivatives I [R = H, Me, Bn, etc.; R1 = C(O)Me, CO2Et, CO2Me], 3-[3-acetyl-2-oxo-tetrahydrofuran-3-yl]-1-benzyl-pyrrolidine-2,5-dione and ethyl-2-[1-benzyl-2,5-dioxo-pyrrolidin-3-yl]-3-oxo-butanoate. The supported quinine catalyst exhibited good catalytic efficiency and modest to high enantioselectivity. The magnetic recoverability and recyclability of the catalyst were also examined The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Category: esters-buliding-blocks
The Article related to silica coated magnetic nanoparticle supported cinchona alkaloid preparation, pyrrolidinedione preparation enantioselective diastereoselective, dione maleimide michael magnetic nanoparticle supported cinchona alkaloid catalyst and other aspects.Category: esters-buliding-blocks
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