On December 12, 2002, Bryant, Judi A.; Buckman, Brad O.; Islam, Imadul; Mohan, Raju; Morrissey, Michael M.; Wei, Guo Pin; Xu, Wei; Yuang, Shendong published a patent.Safety of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the patent was Preparation of 2-[(piperazinocarbonylmethyl)aminocarbonyl]quinolines as platelet adenosine diphosphate receptor antagonists. And the patent contained the following:
The title compounds [I; a, b = 1-4; A = CH, N; R1 = H, alkyl, aryl, etc.; R2 = H, alkyl, aryl, etc.; R3 = H, alkyl, OH, etc.; R4 = H, alkyl, alkoxy, etc.; R5 = H, alkyl, hydroxyalkyl, etc.; R6 = NR7CO, CONR7; R7 = H, alkyl, carboxyalkyl, alkoxycarbonylalkyl], useful as inhibitors of platelet aggregation and thrombus formation, were prepared and formulated. Thus, amidation of 7-methyl-4-hydroxy-2-carboxyquinoline with 4-ethoxycarbonyl-1-[1-amino-3-(1,1-dimethylethoxycarbonyl)propyl]carbonylpiperazine (preparation of both reactants given) afforded 68% I [R1 = CO2Et; R2 = tert-BuOCOCH2CH2; R3 = OH; R4 = 7-Me; R5 = H; R6 = NHCO; A = N]. The compounds I demonstrated their ability to inhibit the binding of [33P]-2-methylthio-ADP binding to the human platelet ADP receptor and the rat platelet ADP receptor. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Safety of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate
The Article related to piperazinocarbonylmethylaminocarbonyl quinoline preparation platelet adenosine diphosphate receptor antagonist antithrombotic, platelet aggregation inhibitor piperazinocarbonylmethylaminocarbonyl quinoline preparation and other aspects.Safety of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate
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